ASSESSMENT OF AN INVITRO METHOD FOR MEASURING THE BIOADHESIVENESS OF TABLETS

被引：13

作者：

JIMENEZCASTELLANOS, MR ^{[1
]}

ZIA, H ^{[1
]}

RHODES, CT ^{[1
]}

机构：

[1] UNIV RHODE ISL,COLL PHARM,DEPT PHARMACEUT,KINGSTON,RI 02881

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 89卷 / 03期

关键词：

ADHESION-SHEAR TEST; BIOADHESION; HYDROPHILIC POLYMER; TABLET; SODIUM CARBOXYMETHYLCELLULOSE; PHENYLPROPANOLAMINE;

D O I：

10.1016/0378-5173(93)90247-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A custom-designed apparatus has been constructed for the quantitative measurement of the bioadhesive properties of controlled release tablets, which measures both the adhesional and frictional forces required to separate two parallel surfaces (tablet/mucosa) from each other, while the tablet and mucus membrane are immersed in a testing medium. Preliminary results obtained for two batches of NaCMC tablets of various polymer contents indicated a good linear relation between maximum adhesion strength and the polymer content. The instrument so designed can be used to estimate the work of removing a bioadhesive tablet from a membrane by either sliding the tablet in a vertical direction or detaching the tablet from the surface.

引用

页码：223 / 228

页数：6

共 12 条

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