DIFFERENT CAPABILITY OF N-METHYL-D-ASPARTATE ANTAGONISTS TO AFFECT LOCOMOTOR/EXPLORATORY ACTIVITY OF MICE IN A COMPUTERIZED ONLINE OPEN-FIELD TEST

被引：32

作者：

DIANA, G ^{[1
]}

SAGRATELLA, S ^{[1
]}

机构：

[1] IST SUPER SANITA,DEPT PHARMACOL,I-00161 ROME,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 48卷 / 01期

关键词：

NMDA; EXPLORATION; LOCOMOTOR ACTIVITY; MICE;

D O I：

10.1016/0091-3057(94)90529-0

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of the competitive N-methyl-D-aspartate (NMDA) antagonists CGS 19755 and CPP, and of the noncompetitive NMDA antagonists PCP, MK 801, and dextromethorphan (DM) have been studied on the locomotor/exploratory activity of mice in a computerized on-line open field test. CGS 19755 (12.5-25 mg/kg, IP) induced a dose-dependent decrease in the locomotor/exploratory activity of mice; CPP (25-50 mg/kg, IP) did not present such an effect. PCP (1.25-10 mg/kg, IF) induced a dose-dependent increase/decrease in the locomotor/exploratory activity of mice, and DM (25-50 mg/kg, IP) and MK 801 (0.125-0.250 mg/kg, IP) increased it. The data show that NMDA antagonists affect locomotor/exploratory activity of mice in different ways, inducing both potentiating and inhibitory effects.

引用

页码：291 / 295

页数：5

共 26 条

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