THE APPLICATION OF POPULATION PHARMACOKINETIC ANALYSIS TO LARGE-SCALE CLINICAL EFFICACY TRIALS

被引：4

作者：

ANTAL, EJ

GRASELA, TH

SMITH, RB

机构：

[1] SUNY BUFFALO,SCH PHARM,DEPT PHARM,BUFFALO,NY 14260

[2] SUNY BUFFALO,SCH MED,DEPT SOCIAL & PREVENT MED,BUFFALO,NY 14260

[3] HARRIS LAB INC,LINCOLN,NE 68502

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1991年 / 19卷 / 03期

关键词：

D O I：

10.1007/BF01371007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Results have been presented that demonstrate the ability to conduct population pharmacokinetic analysis as a component of clinical efficacy and safety trials. This method of analysis offers the potential to determine the pharmacokinetics of a drug in the actual patients receiving medication and to evaluate relationships between pharmacokinetics and drug action. However, active involvement in the protocol design, and data collection process are required to ensure the quality of the resultant data set. © 1991 Plenum Publishing Corporation.

引用

页码：S37 / S46

页数：10

共 6 条

[1]

ANTAL EJ, 1989, IN PRESS CLIN PHARM

[2]

BALLENGER JC, 1988, ARCH GEN PSYCHIAT, V45, P413

[3]

BALLENGER JC, 1986, APR PHARM PHARM STUD

[4]

Beal S, 1989, NONMEM USERS GUIDES