HUMAN HEPATOCYTE GROWTH-FACTOR STIMULATES THE GROWTH OF HUH-6 CLONE-5 HUMAN HEPATOBLASTOMA CELLS

被引：41

作者：

MIYAZAKI, M

GOHDA, E

TSUBOI, S

TSUBOUCHI, H

DAIKUHARA, Y

NAMBA, M

YAMAMOTO, I

机构：

[1] OKAYAMA UNIV,FAC PHARMACEUT SCI,DEPT IMMUNOCHEM,OKAYAMA 700,JAPAN

[2] OKAYAMA UNIV,INST MOLEC & CELLULAR BIOL,DEPT CELL BIOL,OKAYAMA 700,JAPAN

[3] KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 2,KAGOSHIMA 890,JAPAN

[4] KAGOSHIMA UNIV,SCH DENT,DEPT BIOCHEM,KAGOSHIMA 890,JAPAN

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1992年 / 16卷 / 02期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0309-1651(06)80108-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 Clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody. © 1992 Academic Press Ltd.

引用

页码：145 / 154

页数：10

共 32 条

[1] CONTROLLED SYNTHESIS OF HBSAG IN A DIFFERENTIATED HUMAN-LIVER CARCINOMA-DERIVED CELL-LINE [J].