HUMAN HEPATOCYTE GROWTH-FACTOR STIMULATES THE GROWTH OF HUH-6 CLONE-5 HUMAN HEPATOBLASTOMA CELLS

被引:41
作者
MIYAZAKI, M
GOHDA, E
TSUBOI, S
TSUBOUCHI, H
DAIKUHARA, Y
NAMBA, M
YAMAMOTO, I
机构
[1] OKAYAMA UNIV,FAC PHARMACEUT SCI,DEPT IMMUNOCHEM,OKAYAMA 700,JAPAN
[2] OKAYAMA UNIV,INST MOLEC & CELLULAR BIOL,DEPT CELL BIOL,OKAYAMA 700,JAPAN
[3] KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 2,KAGOSHIMA 890,JAPAN
[4] KAGOSHIMA UNIV,SCH DENT,DEPT BIOCHEM,KAGOSHIMA 890,JAPAN
基金
日本学术振兴会;
关键词
D O I
10.1016/S0309-1651(06)80108-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 Clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody. © 1992 Academic Press Ltd.
引用
收藏
页码:145 / 154
页数:10
相关论文
共 32 条
[1]   CONTROLLED SYNTHESIS OF HBSAG IN A DIFFERENTIATED HUMAN-LIVER CARCINOMA-DERIVED CELL-LINE [J].
ADEN, DP ;
FOGEL, A ;
PLOTKIN, S ;
DAMJANOV, I ;
KNOWLES, BB .
NATURE, 1979, 282 (5739) :615-616
[2]  
ALEXANDER JJ, 1976, S AFR MED J, V50, P2124
[3]  
ASAMI O, 1991, J BIOCHEM-TOKYO, V109, P8
[4]   IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].
BOTTARO, DP ;
RUBIN, JS ;
FALETTO, DL ;
CHAN, AML ;
KMIECIK, TE ;
VANDEWOUDE, GF ;
AARONSON, SA .
SCIENCE, 1991, 251 (4995) :802-804
[5]  
DOI I, 1976, GANN, V67, P1
[6]  
DOI I, 1975, GANN, V66, P385
[7]  
GOHDA E, 1990, LIFE SCI, V46, P1801
[8]   BIOLOGICAL AND IMMUNOLOGICAL PROPERTIES OF HUMAN HEPATOCYTE GROWTH-FACTOR FROM PLASMA OF PATIENTS WITH FULMINANT HEPATIC-FAILURE [J].
GOHDA, E ;
YAMASAKI, T ;
TSUBOUCHI, H ;
KUROBE, M ;
SAKIYAMA, O ;
AOKI, H ;
NIIDANI, N ;
SHIN, S ;
HAYASHI, K ;
HASHIMOTO, S ;
DAIKUHARA, Y ;
YAMAMOTO, I .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1053 (01) :21-26
[9]   HUMAN HEPATOCYTE GROWTH-FACTOR IN BLOOD OF PATIENTS WITH FULMINANT HEPATIC-FAILURE - BASIC ASPECTS [J].
GOHDA, E ;
TSUBOUCHI, H ;
NAKAYAMA, H ;
HIRONO, S ;
ARAKAKI, N ;
YAMAMOTO, I ;
HASHIMOTO, S ;
DAIKUHARA, Y .
DIGESTIVE DISEASES AND SCIENCES, 1991, 36 (06) :785-790
[10]   PURIFICATION AND PARTIAL CHARACTERIZATION OF HEPATOCYTE GROWTH-FACTOR FROM PLASMA OF A PATIENT WITH FULMINANT HEPATIC-FAILURE [J].
GOHDA, E ;
TSUBOUCHI, H ;
NAKAYAMA, H ;
HIRONO, S ;
SAKIYAMA, O ;
TAKAHASHI, K ;
MIYAZAKI, H ;
HASHIMOTO, S ;
DAIKUHARA, Y .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (02) :414-419