STEREOSELECTIVE VINYLATION OF AMINO ALDEHYDES USING 2-TRIMETHYLSILYLETHYLIDENTRIPHENYLPHOSPHORANE

被引：23

作者：

FRANCIOTTI, M

MANN, A

TADDEI, M

机构：

[1] UNIV FLORENCE,DIPARTIMENTO CHIM ORGAN UGO SCHIFF,VIA G CAPPONI 9,I-50121 FLORENCE,ITALY

[2] CNRS,CTR NEUROCHIM,PHARMACOCHIM MOLEC LAB,F-67084 STRASBOURG,FRANCE

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)93602-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Trimethylsilylethylidentriphenylphosphorane reacts stereoselectively with alpha-amino aldehydes giving the Cram chelation controlled product of vinylation of the carbonyl group. The olefinic 1,2-amino alcohols obtained with this reaction are important intermediates for the preparation of peptides analogues and they were employed for the preparation of N-Boc-statine.

引用

页码：6783 / 6786

页数：4

共 22 条

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