STEREOSELECTIVE VINYLATION OF AMINO ALDEHYDES USING 2-TRIMETHYLSILYLETHYLIDENTRIPHENYLPHOSPHORANE

被引:23
作者
FRANCIOTTI, M
MANN, A
TADDEI, M
机构
[1] UNIV FLORENCE,DIPARTIMENTO CHIM ORGAN UGO SCHIFF,VIA G CAPPONI 9,I-50121 FLORENCE,ITALY
[2] CNRS,CTR NEUROCHIM,PHARMACOCHIM MOLEC LAB,F-67084 STRASBOURG,FRANCE
关键词
D O I
10.1016/S0040-4039(00)93602-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
2-Trimethylsilylethylidentriphenylphosphorane reacts stereoselectively with alpha-amino aldehydes giving the Cram chelation controlled product of vinylation of the carbonyl group. The olefinic 1,2-amino alcohols obtained with this reaction are important intermediates for the preparation of peptides analogues and they were employed for the preparation of N-Boc-statine.
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页码:6783 / 6786
页数:4
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