TISSUE PENETRATION OF CLINDAMYCIN IN DIABETIC FOOT INFECTIONS

被引：38

作者：

DUCKWORTH, C

FISHER, JF

CARTER, SA

NEWMAN, CL

COGBURN, C

NESBIT, RR

WRAY, CH

机构：

[1] MED COLL GEORGIA,DEPT MED,AUGUSTA,GA 30912

[2] MED COLL GEORGIA,DEPT SURG,AUGUSTA,GA 30912

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1993年 / 31卷 / 04期

关键词：

D O I：

10.1093/jac/31.4.581

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving cindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0·04-2·8 mg/kg in tissues and 1·1-11·1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0·13. © 1993 The British Society for Antimicrobial Chemotherapy.

引用

页码：581 / 584

页数：4

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