INVOLVEMENT OF THIOLS IN THE INDUCTION OF INWARD CURRENT-INDUCED BY SILVER IN FROG SKELETAL-MUSCLE MEMBRANE

被引：9

作者：

AOKI, T

NIHONYANAGI, K

OBA, T

机构：

[1] NAGOYA CITY UNIV,SCH MED,DEPT PHYSIOL,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

[2] GIFU CITY WOMENS COLL,DEPT FOOD & NUTR SCI,GIFU 502,JAPAN

来源：

EXPERIENTIA | 1993年 / 49卷 / 09期

关键词：

SILVER ION; CALCIUM CHANNEL; INWARD CURRENT; SH GROUP; CONTRACTION; SKELETAL MUSCLE DETERIORATION;

D O I：

10.1007/BF01923550

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exposure of voltage-clamped frog skeletal muscle fibres to silver caused a maintained inward current which could be carried by Ca2+, Mg2+ or Na+. Inorganic Ca2+ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na+ channel blocker did not. Thus, silver activates the Ca2+ channel by acting on SH groups in a Ca2+ channel protein.

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页码：792 / 794

页数：3

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