DIRECT COUPLING OF FUNCTIONALIZED ORGANOLITHIUM COMPOUNDS WITH ARYL AND VINYL HALIDES

被引：35

作者：

BARLUENGA, J

MONTSERRAT, JM

FLOREZ, J

机构：

[1] Departamento de Química Organometálica, Facultad de Química, Universidad de Oviedo

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 22期

关键词：

D O I：

10.1021/jo00074a025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction between beta- and gamma-nitrogen-functionalized and gamma- and epsilon-oxygen-functionalized organolithium compounds 3, 4, 30-32 and different aromatic, heteroaromatic, and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 5-26 and alcohols 33-37. Symmetrical and mixed products of double coupling 38-40 were also prepared from 1,4-diiodobenzene. The formation of alkyl halides as intermediates has been verified. Aryl or vinyl halides giving rise to unstable aryl or vinyllithium reagents were unsuccessful in the coupling reaction.

引用

页码：5976 / 5980

页数：5

共 36 条

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