A NONPEPTIDE AGONIST OF THE INVERTEBRATE RECEPTOR FOR SCHISTOFLRFAMIDE (PDVDHVFLRFAMIDE), A MEMBER OF A SUBFAMILY OF INSECT FMRFAMIDE-RELATED PEPTIDES

被引：35

作者：

LANGE, AB

ORCHARD, I

WANG, ZX

NACHMAN, RJ

机构：

[1] USDA ARS,FOOD ANIM PROTECT RES LAB,VET ENTOMOL RES UNIT,COLLEGE STN,TX 77845

[2] UNIV TORONTO,DEPT ZOOL,TORONTO,ON M5S 1A1,CANADA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 20期

关键词：

D O I：

10.1073/pnas.92.20.9250

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe a nonpeptide mimetic analog of an invertebrate peptide receptor, Benzethonium chloride (Bztc) is an agonist of the SchistoFLRFamide (PDVDHVFLRFamide) receptors found on locust oviducts. Bztc competitively displaces [I-125-labeled Y-1] SchistoFLRFamide binding to both high- and low-affinity receptors of membrane preparations. Bztc mimics the physiological effects of SchistoFLRFamide on locust oviduct, by inhibiting myogenic and induced contractions in a dose-dependent manner. Bztc is therefore recognized by the binding and activation regions of the SchistoFLRFamide receptors, This discovery provides a unique opportunity within insects to finally target a peptide receptor for the development of future pest management strategies,

引用

收藏

页码：9250 / 9253

页数：4

相关论文

共 16 条

[1] DESIGN OF POTENT, ORALLY EFFECTIVE, NONPEPTIDAL ANTAGONISTS OF THE PEPTIDE-HORMONE CHOLECYSTOKININ [J].

EVANS, BE ;

BOCK, MG ;

RITTLE, KE ;

DIPARDO, RM ;

WHITTER, WL ;

VEBER, DF ;

ANDERSON, PS ;

FREIDINGER, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4918-4922

[2] ISOLATION, PRIMARY STRUCTURE AND SYNTHESIS OF LEUKOMYOSUPPRESSIN, AN INSECT NEUROPEPTIDE THAT INHIBITS SPONTANEOUS CONTRACTIONS OF THE COCKROACH HINDGUT [J].

HOLMAN, GM ;

COOK, BJ ;

NACHMAN, RJ .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1986, 85 (02) :329-333

[3] EVIDENCE FOR THE INVOLVEMENT OF A SCHISTOFLRF-AMIDE-LIKE PEPTIDE IN THE NEURAL CONTROL OF LOCUST OVIDUCT [J].

LANGE, AB ;

ORCHARD, I ;

TEBRUGGE, VA .

JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 1991, 168 (03) :383-391

[4] INSECT NEUROPEPTIDES - DISCOVERY AND APPLICATION IN INSECT MANAGEMENT [J].

MASLER, EP ;

KELLY, TJ ;

MENN, JJ .

ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1993, 22 (1-2) :87-111

[5] STRUCTURE-ACTIVITY-RELATIONSHIPS FOR INHIBITORY INSECT MYOSUPPRESSINS - CONTRAST WITH THE STIMULATORY SULFAKININS [J].

NACHMAN, RJ ;

HOLMAN, GM ;

HAYES, TK ;

BEIER, RC .

PEPTIDES, 1993, 14 (04) :665-670

[6]

NACHMAN RJ, 1994, INSECT NEUROCHEMISTRY AND NEUROPHYSIOLOGY 1993, P319

[7] LEADS FOR INSECT NEUROPEPTIDE MIMETIC DEVELOPMENT [J].

NACHMAN, RJ ;

HOLMAN, GM ;

HADDON, WF .

ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1993, 22 (1-2) :181-197

[8]

NACHMAN RJ, 1994, NATURAL ENG PEST MAN, P210

[9] ISOLATION, SEQUENCE, AND BIOACTIVITY OF PDVDHVFLRFAMIDE AND ADVGHVFLRFAMIDE PEPTIDES FROM THE LOCUST CENTRAL-NERVOUS-SYSTEM [J].

PEEFF, NM ;

ORCHARD, I ;

LANGE, AB .

PEPTIDES, 1994, 15 (03) :387-392

[10] ISOLATION, PRIMARY STRUCTURE AND BIOACTIVITY OF SCHISTOFLRF-AMIDE, A FMRF-AMIDE-LIKE NEUROPEPTIDE FROM THE LOCUST, SCHISTOCERCA-GREGARIA [J].

ROBB, S ;

PACKMAN, LC ;

EVANS, PD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (02) :850-856