BINDING OF ARYLPIPERAZINES TO 5-HT3 SEROTONIN RECEPTORS - RESULTS OF A STRUCTURE-AFFINITY STUDY

被引：70

作者：

GLENNON, RA ^{[1
]}

ISMAIEL, AEM ^{[1
]}

MCCARTHY, BG ^{[1
]}

PEROUTKA, SJ ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,DEPT NEUROL,STANFORD,CA 94305

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1989年 / 168卷 / 03期

关键词：

D O I：

10.1016/0014-2999(89)90802-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：387 / 392

页数：6

共 16 条

[1] [H-3] ZACOPRIDE - LIGAND FOR THE IDENTIFICATION OF 5-HT3 RECOGNITION SITES [J].

BARNES, NM ;

COSTALL, B ;

NAYLOR, RJ .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (08) :548-551

[2] PROPOSALS FOR THE CLASSIFICATION AND NOMENCLATURE OF FUNCTIONAL RECEPTORS FOR 5-HYDROXYTRYPTAMINE [J].

BRADLEY, PB ;

ENGEL, G ;

FENIUK, W ;

FOZARD, JR ;

HUMPHREY, PPA ;

MIDDLEMISS, DN ;

MYLECHARANE, EJ ;

RICHARDSON, BP ;

SAXENA, PR .

NEUROPHARMACOLOGY, 1986, 25 (06) :563-576

[3]

COSTALL B, 1988, REV NEUROSCI, V2, P41

[4] 5-HT1 AND 5-HT2 BINDING CHARACTERISTICS OF SOME QUIPAZINE ANALOGS [J].

GLENNON, RA ;

SLUSHER, RM ;

LYON, RA ;

TITELER, M ;

MCKENNEY, JD .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) :2375-2380

[5]

GLENNON RA, 1989, RECEPTOR PHARM FUNCT, P2577

[6]

HOYER D, 1988, MOL PHARMACOL, V33, P303

[7] IDENTIFICATION AND DISTRIBUTION OF 5-HT3 RECEPTORS IN RAT-BRAIN USING RADIOLIGAND BINDING [J].

KILPATRICK, GJ ;

JONES, BJ ;

TYERS, MB .

NATURE, 1987, 330 (6150) :746-748

[8]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[9] SYNTHESIS AND EVALUATION OF PHENYL-PIPERAZINES AND BENZOYLPIPERAZINES AS POTENTIAL SEROTONERGIC AGENTS [J].

LYON, RA ;

TITELER, M ;

MCKENNEY, JD ;

MAGEE, PS ;

GLENNON, RA .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (05) :630-634

[10]

MILBURN CM, IN PRESS J NEUROCHEM

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