CYTOGENETIC STUDIES IN COUPLES EXPERIENCING REPEATED PREGNANCY LOSSES

被引：174

作者：

DEBRAEKELEER, M

DAO, TN

机构：

[1] SOREP, Inter-University Centre for Research on Populations, University of Quebec at Chicoutimi, Chicoutimi, QC G7H 2B1

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 05期

关键词：

Chromosome abnormalities; Cytogenetic studies; Genetic counselling; Pregnancy loss;

D O I：

10.1093/oxfordjournals.humrep.a137135

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A computerized database generated from the literature on cytogenetic studies in couples experiencing repeated pregnancy losses has been set up at the University of Quebec at Chicoutimi. At the present time, it contains data on 22 199 couples (44 398 individuals). The statistical analyses showed a relationship between the distribution of the chromosome abnormalities and the number of abortions. An uneven distribution of the chromosomal structural rearrangements according to the sex of the carrier was found (P < 0.05). Overall, 4.7% of the couples ascertained for two or more spontaneous abortions included one carrier. It also appeared that only translations (both reciprocal and Robertsonian) and inversions were associated with a higher risk of pregnancy wastage. Therefore, genetic counselling should be offered to these couples and investigations performed on their extended families. © 1990 Oxford University Press.

引用

页码：519 / 528

页数：10

共 69 条

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