DEMONSTRATION OF RNA N-GLYCOSIDASE ACTIVITY OF A VERO TOXIN (VT2 VARIANT) PRODUCED BY ESCHERICHIA-COLI O91-H21 FROM A PATIENT WITH THE HEMOLYTIC UREMIC SYNDROME

被引：27

作者：

FURUTANI, M

ITO, K

OKU, Y

TAKEDA, Y

IGARASHI, K

机构：

[1] CHIBA UNIV,FAC PHARMACEUT SCI,CHIBA 260,JAPAN

[2] UNIV TOKYO,INST MED SCI,DEPT BACTERIAL INFECT,MINAN KU,TOKYO 108,JAPAN

[3] KYOTO UNIV,FAC MED,DEPT MICROBIOL,SAKYO KU,KYOTO 606,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1990年 / 34卷 / 04期

关键词：

D O I：

10.1111/j.1348-0421.1990.tb01019.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A new Vero toxin purified from Escherichia coli 091: :H21 isolated from a patient with the hemolytic uremic syndrome (VT2vh) was shown to inhibit elongation factor 1-dependent aminoacyl-tRNA binding to ribosomes, resulting in inhibition of protein synthesis in rabbit reticulocytes. VT2vh, like Shiga toxin, VT1 and VT2, showed RNA N-glycosidase activity and cleaved the N-glycosidic bond of the adenosine residue at position 4324 in 28S ribosomal RNA. © 1990, Center For Academic Publications Japan. All rights reserved.

引用

页码：387 / 392

页数：6

共 17 条

[1]

ENDO Y, 1982, J BIOL CHEM, V257, P9054

[2]

ENDO Y, 1987, J BIOL CHEM, V262, P5908

[3] SITE OF ACTION OF A VERO TOXIN (VT2) FROM ESCHERICHIA-COLI O157-H7 AND OF SHIGA TOXIN ON EUKARYOTIC RIBOSOMES - RNA N-GLYCOSIDASE ACTIVITY OF THE TOXINS [J].