THE HLA-DRB1-ASTERISK-0405 HAPLOTYPE IS MOST STRONGLY ASSOCIATED WITH IDDM IN ALGERIANS

被引:29
作者
DJOULAH, S
KHALIL, I
BERESSI, JP
BENHAMAMOUCH, S
BESSAOUD, K
DESCHAMPS, I
DEGOS, L
HORS, J
机构
[1] HOP ST LOUIS,CTR HAYEM,INSERM,U93,1 AVE CL VELLEFAUX,F-75475 PARIS 10,FRANCE
[2] ES SENIA UNIV,INST BIOL,ORAN,ALGERIA
[3] ES SENIA UNIV,GENET LAB,ORAN,ALGERIA
[4] AMILCAR CABRAL PEDIAT CLIN,ORAN,ALGERIA
[5] HOP NECKER ENFANTS MALAD,INSERM,U30,F-75730 PARIS 15,FRANCE
来源
EUROPEAN JOURNAL OF IMMUNOGENETICS | 1992年 / 19卷 / 06期
关键词
D O I
10.1111/j.1744-313X.1992.tb00081.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Insulin-dependent diabetes mellitus (IDDM) in Caucasians is strongly associated with HLA-DR3-DQ2 and DR4-DQ8. In order to investigate the HLA class II associations with IDDM in Algerians, we have used polymerase chain reaction (PCR) and sequence specific oligonucleotide analysis (SSO) to identify DQA1, DQB1, and DRB1 alleles, haplotypes and genotypes in 50 unrelated IDDM patients and 46 controls from a homogeneous population in Western Algeria. Both DRB1*0301-DQA1*0501-DQB1*0201 (DR3-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) haplotypes were found at increased frequencies among the patients compared to controls (45% vs. 13%, RR = 5.5, P(c) < 10(-5) and 37% vs. 4%, RR = 12.9, P(c) < 10(-4), respectively). Among the latter, in contrast to other Caucasian populations, only DRB1*0405-DQA1*0301-DQB1*0302 was significantly increased in the Algerian patients (25% vs. 1% in controls, RR = 30.3, P(c) < 10(-3)) . Accordingly, the highest risk of disease was observed in DRB1*0301-DQA1*0501-DQB1*0201/DRB1 *0405-DQA1*0301-DQB1*0302 heterozygotes (34% in patients vs. 0% in controls; RR = 49; P(c) < 10(-3)). This observation and its comparison with DR-DQ haplotypes in other ethnic groups suggest that the DRB1*0405 allele which encodes an Asp57-negative beta chain may contribute to IDDM susceptibility in a similar way as Asp57-negative DQbeta chains.
引用
收藏
页码:381 / 389
页数:9
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