RELATIONSHIP BETWEEN FATTY LIVER, ALANINE AMINOTRANSFERASE, HBSAG AND HEPATITIS-C VIRUS

被引:13
作者
CHANG, WY
CHEN, CJ
LU, SN
YOU, SL
CHUANG, WL
CHEN, SC
SU, WP
WANG, LY
HSIEH, MY
WU, MM
TAI, TY
机构
[1] NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED,TAIPEI,TAIWAN
[2] ACAD SINICA,INST BIOMED SCI,TAIPEI 115,TAIWAN
关键词
ALANINE TRANSAMINASE; CHINESE; COMMUNITY SURVEY; FATTY LIVER; HEPATITIS-B SURFACE ANTIGEN; HEPATITIS-C VIRUS;
D O I
10.1111/j.1440-1746.1992.tb01019.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A community health survey of 923 residents aged 30 years or more was performed in Putai Township of Taiwan. To elucidate the relationships between hepatitis C virus (HCV) and surrogate tests for non-A, non-B hepatitis in hyperendemic areas of hepatitis B virus (HBV) serum levels of alanine aminotransferase (ALT), triglycerides, cholesterol, hepatitis B surface antigen (HBsAg) and antibody to HCV (anti-HCV) were examined. Glucose tolerance tests and the history of diabetes treatment were used to define the diabetes status. Fatty liver was diagnosed by sonography. The prevalence of anti-HCV was 2.6% (95% confidence interval, 1.6-3.6%). Elevated ALT and fatty liver were significantly associated with anti-HCV in univariate analysis. Anti-HCV was not an associated factor for fatty liver after adjusting for serum triglycerides and cholesterol, sex, body mass index and diabetes status through multiple logistic regression. However elevated ALT was still associated with anti-HCV after adjusting for serum triglycerides, sex, body mass index, HBsAg and age through multiple linear regression. The anti-HCV prevalence was similar between HBsAg-positive and negative subjects. Aggregation of HCV infection was found among spouses. It was concluded that elevated ALT and intimate contact with HCV carriers might be associated factors for HCV infection, and that HBV infection and fatty liver were not related to HCV infection in Taiwan.
引用
收藏
页码:455 / 458
页数:4
相关论文
共 22 条
[1]   IMPORTANCE OF HETEROSEXUAL ACTIVITY IN THE TRANSMISSION OF HEPATITIS-B AND NON-A, NON-B HEPATITIS [J].
ALTER, MJ ;
COLEMAN, PJ ;
ALEXANDER, WJ ;
KRAMER, E ;
MILLER, JK ;
MANDEL, E ;
HADLER, SC ;
MARGOLIS, HS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 262 (09) :1201-1205
[2]  
Bianchi L, 1983, Prog Clin Biol Res, V143, P67
[3]   SERUM ALT LEVELS - EFFECT OF SEX, RACE, AND OBESITY ON UNIT REJECTION RATE [J].
BRIERE, RO .
TRANSFUSION, 1988, 28 (04) :392-393
[4]  
BRUIX J, 1989, LANCET, V2, P1004
[5]   HEPATITIS-C VIRUS-INFECTION IN AN AREA HYPERENDEMIC FOR HEPATITIS-B AND CHRONIC LIVER-DISEASE - THE TAIWAN EXPERIENCE [J].
CHEN, DS ;
KUO, GC ;
SUNG, JL ;
LAI, MY ;
SHEU, JC ;
CHEN, PJ ;
YANG, PM ;
HSU, HM ;
CHANG, MH ;
CHEN, CJ ;
HAHN, LC ;
CHOO, QL ;
WANG, TH ;
HOUGHTON, M .
JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (04) :817-822
[6]   HEPATITIS-C VIRUS - THE MAJOR CAUSATIVE AGENT OF VIRAL NON-A, NON-B HEPATITIS [J].
CHOO, QL ;
WEINER, AJ ;
OVERBY, LR ;
KUO, G ;
HOUGHTON, M ;
BRADLEY, DW .
BRITISH MEDICAL BULLETIN, 1990, 46 (02) :423-441
[7]   A MULTICENTER, PROSPECTIVE-STUDY OF POSTTRANSFUSION HEPATITIS IN MILAN [J].
COLOMBO, M ;
OLDANI, S ;
DONATO, MF ;
BORZIO, M ;
SANTESE, R ;
ROFFI, L ;
VIGANO, P ;
CARGNEL, A .
HEPATOLOGY, 1987, 7 (04) :709-712
[8]  
FOSTER DW, 1987, HARRISONS PRINCIPLES, P1778
[9]   THE ACCURACY OF ULTRASOUND IN THE DETECTION OF FATTY INFILTRATION OF THE LIVER [J].
FOSTER, KJ ;
DEWBURY, KC ;
GRIFFITH, AH ;
WRIGHT, R .
BRITISH JOURNAL OF RADIOLOGY, 1980, 53 (629) :440-442
[10]   ACCURACY OF ULTRASONOGRAPHY IN DIAGNOSIS OF HEPATOCELLULAR DISEASE [J].
GOSINK, BB ;
LEMON, SK ;
SCHEIBLE, W ;
LEOPOLD, GR .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1979, 133 (01) :19-23