ANALYSIS OF DYNAMIN ISOFORMS IN MAMMALIAN BRAIN - DYNAMIN-1 EXPRESSION IS SPATIALLY AND TEMPORALLY REGULATED DURING POSTNATAL-DEVELOPMENT

被引:45
作者
FAIRE, K [1 ]
TRENT, F [1 ]
TEPPER, JM [1 ]
BONDER, EM [1 ]
机构
[1] RUTGERS STATE UNIV,CTR MOLEC & BEHAV NEUROSCI,NEWARK,NJ 07102
关键词
SYNAPTOGENESIS; CYTOSKELETON; MICROTUBULE-ASSOCIATED PROTEIN; NEUROGENESIS;
D O I
10.1073/pnas.89.17.8376
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In adult rat brain, the microtubule-associated protein dynamin is composed of a closely spaced polypeptide doublet of almost-equal-to 100 kDa. Using an antibody preparation that is monospecific for dynamin-1 (the higher molecular mass isoform) we examined the temporal and regional expression of dynamin-1 in developing rat brain. Analysis of whole rat brain homogenates established that prior to postnatal day 9, dynamin-1 was present only at very low levels and thereafter its expression steadily increased with adult levels being attained by postnatal day 23. In individual regions of the brain, dynamin-1 levels were highest in cortex, amygdala, and striatum, significantly lower in olfactory bulb, cerebellum, and midbrain, and lowest in brainstem. During postnatal development, each of the regions exhibited approximately the same time course of protein expression except for a slight lag in expression in olfactory bulb. The spatial and temporal patterns of expression of dynamin-1 correlate with the establishment and/or maintenance of mature neuronal structure and function rather than dendritic or axonal outgrowth.
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页码:8376 / 8380
页数:5
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