IMMUNOLOGICAL ASPECTS OF A CASE OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER

被引：5

作者：

FRANCO, A

MUNOZ, C

ARANDA, I

CABEZAS, A

PERDIGUERO, M

PRADOS, C

机构：

[1] GEN HOSP ALICANTE,DEPT IMMUNOL,ALACANT,SPAIN

[2] GEN HOSP ALICANTE,DEPT PATHOL,ALACANT,SPAIN

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1995年 / 15卷 / 02期

关键词：

EPSTEIN-BARR VIRUS; IMMUNOGLOBULIN D; KIDNEY TRANSPLANTATION; LYMPHOPROLIFERATIVE DISORDER; BETA(2)-MICROGLOBULIN;

D O I：

10.1159/000168818

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a female renal transplant recipient with cytomegalovirus and Epstein-Barr virus (EBV) infections who developed agressive polymorphous polyclonal B cell proliferation. She received two courses of OKT3. We found a majority of transformed B cells bearing EBV membrane receptor CR2 and EBV nuclear antigen. Posttransplant lymphoproliferative disorders may be associated with a significant immunological activation, detected in this case by the sudden increase of beta(2)-microglobulin and immunoglobulin levels, including immunoglobulin D. These raised levels persisted throughout the short and rapid course of the disease.

引用

页码：137 / 141

页数：5

共 17 条

[1] A RECENT DECREASE IN THE TIME TO DEVELOPMENT OF MONOMORPHOUS AND POLYMORPHOUS POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER [J].