Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide

被引：89

作者：

Mahoney, MM ^{[1
]}

Lee, AY ^{[1
]}

BrezinskiCaliguri, DJ ^{[1
]}

Huttner, KM ^{[1
]}

机构：

[1] BOSTON CHILDRENS HOSP,DEPT MED,PROGRAM NEONATOL,BOSTON,MA 02115

来源：

FEBS LETTERS | 1995年 / 377卷 / 03期

关键词：

ovine; cathelin; 3' RACE; antimicrobial peptide;

D O I：

10.1016/0014-5793(95)01390-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cathelin-related genes are characterized by the presence of a prepro sequence which is highly conserved both within and between species, 3' RACE analysis on sheep bone marrow RNA, using a primer based on a conserved cathelin family coding region, demonstrated the presence of at least three ovine cathelin-related cDNAs, One of these encodes a novel prepropeptide with a predicted C-terminal cleavage product RGLRRLGRKIAHG-VKKYGPTVLRIIRIAG. The chemically synthesized form of this 29 amino acid peptide is shown to be a thermostable, broad spectrum, bactericidal agent.

引用

页码：519 / 522

页数：4

共 20 条

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