AN ANTITUMOR NECROSIS FACTOR ANTIBODY SUPPRESSES SLEEP IN RATS AND RABBITS

被引：51

作者：

TAKAHASHI, S ^{[1
]}

KAPAS, L ^{[1
]}

FANG, JD ^{[1
]}

KRUEGER, JM ^{[1
]}

机构：

[1] UNIV TENNESSEE,DEPT PHYSIOL & BIOPHYS,MEMPHIS,TN 38163

来源：

BRAIN RESEARCH | 1995年 / 690卷 / 02期

关键词：

TUMOR NECROSIS FACTOR; SLEEP SUPPRESSION; RAT; RABBIT;

D O I：

10.1016/0006-8993(95)00609-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electro encephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten mu g TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 mu g TNFab did not affect sleep but decreased brain temperature; in contrast, 25 mu g TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.

引用

页码：241 / 244

页数：4

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