EFFECT OF TYPE-A PASTEURELLA-MULTOCIDA FRACTIONS ON BOVINE POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS

被引：20

作者：

RYU, H

KAEBERLE, ML

ROTH, JA

GRIFFITH, RW

机构：

来源：

INFECTION AND IMMUNITY | 1984年 / 43卷 / 01期

关键词：

D O I：

10.1128/IAI.43.1.66-71.1984

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of various P. multocida fractions on bovine polymorphonuclear leukocyte (PMN) functions was examined in vitro by using 2 encapsulated strains, P-2383 and P-1062 (both are Carter capsular type A and of bovine origin). The ability of PMN to ingest Staphylococcus aureus and iodinate protein was significantly inhibited in the presence of live cells, heat-killed whole cells or saline-extracted capsules, but not in the presence of the decapsulated heat-killed cells. None of the fractions of the 2 strains inhibited nitroblue tetrazolium reduction by PMN. The saline extract did not inhibit the binding of I to protein by a reaction involving xanthine, xanthine oxidase and horseradish peroxidase. The PMN inhibitory factor was further characterized as a heat-stable capsular material of > 300,000 MW.

引用

页码：66 / 71

页数：6

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