ACYCLOVIR-INDUCED RENAL-FAILURE - COURSE AND RISK FACTOR

被引：36

作者：

BIANCHETTI, MG ^{[1
]}

RODUIT, C ^{[1
]}

OETLIKER, OH ^{[1
]}

机构：

[1] INSELSPITAL BERN,UNIV CHILDRENS HOSP,DEPT PAEDIAT,CH-3010 BERN,SWITZERLAND

来源：

PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 02期

关键词：

ACYCLOVIR; ACUTE RENAL FAILURE; ENCEPHALITIS; NEPHROTOXIC DRUGS; INTRATUBULAR CRYSTALLURIA;

D O I：

10.1007/BF01095963

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Of 19 children treated with high-dose intravenous acyclovir, 7, all of whom had encephalitis, also had a restricted fluid intake. Of these, 3 experienced nonoliguric renal insufficiency (plasma creatinine up to 176, 250 and 351-mu-mol/l, respectively) which resolved within 1 week of discontinuing acyclovir. Renal function was stable in the remaining 4 patients in this group and in the 12 children treated with acyclovir but without fluid restriction. We suggest the decreased renal function resulted from intratubular acyclovir crystalluria.

引用

页码：238 / 239

页数：2

共 9 条

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