POTENT ORAL ANTICONVULSANT ACTION OF CPP AND CPPENE IN DBA/2 MICE

CPP (3-(2-carboxypiperazine-4-yl)-1-phosphonate), and its unsaturated analogue, CPPene (3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid), have potent anticonvulsant activity against sound-induced clortic seizures in DBA/2 mice. Following i.p. adminstration the protection is maximal at 1-2 h, and the ED50, values (μ mol/kg) are: D(-)-CPPene, 1.54; D(-)-CPP, 2.75; D,L(±)-CPP, 4.36. Following oral administration the protection is maximal at 3-4 h and the ED50 (μ mol/kg) values are: D(-)-CPPene, 40,19: D(-)-CPP, 65.80; D,L(±)-CPP, 108.1. © 1990.