SYNTHESIS AND ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF PYRROLE-CONTAINING ANALOGS OF TRICHOSTATIN-A

被引：26

作者：

MASSA, S

ARTICO, M

CORELLI, F

MAI, A

DISANTO, R

CORTES, S

MARONGIU, ME

PANI, A

LACOLLA, P

机构：

[1] UNIV ROME LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT,P LE ALDO MORO 5,I-00185 ROME,ITALY

[2] UNIV SIENA,DIPARTIMENTO FARMACO CHIM TECNOL,I-53100 SIENA,ITALY

[3] UNIV CAGLIARI,DIPARTIMENTO BIOL SPERIMENTALE,SEZ MICROBIOL,I-09124 CAGLIARI,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 10期

关键词：

D O I：

10.1021/jm00172a026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of aroylpyrroleacrylic acid derivatives were synthesized by standard procedures and evaluated for cytotoxicity in Vero cells and for capacity to inhibit the multiplication of viruses, bacteria, and fungi. While none of the test compounds showed any activity against bacteria and fungi, most of them inhibited the replication of some DNA viruses at concentrations allowing the exponential growth of uninfected cells. In particular three compounds (8, 9c, and lOh) showed an antiviral activity at doses that were from 4- to <8-fold lower than the maximum nontoxic doses. © 1990, American Chemical Society. All rights reserved.

引用

页码：2845 / 2849

页数：5

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