PEG-BOVINE HEMOGLOBIN - SAFETY IN A CANINE DEHYDRATED HYPOVOLEMIC-HEMORRHAGIC SHOCK MODEL

被引：52

作者：

NHO, K

GLOWER, D

BREDEHOEFT, S

SHANKAR, H

SHORR, R

ABUCHOWSKI, A

机构：

[1] DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710

[2] ENZON,DEPT RES,S PLAINFIELD,NJ 07080

来源：

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1992年 / 20卷 / 2-4期

关键词：

D O I：

10.3109/10731199209119677

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.

引用

页码：511 / 524

页数：14

共 17 条

[1] SYNTHESIS OF POLYMER-BOUND HEMOGLOBIN SAMPLES [J].