FURTHER CHARACTERIZATION OF MITOCHONDRIAL OUTER-MEMBRANE - EVIDENCE FOR THE PRESENCE OF 2 ENDOGENOUS SIALYLATED GLYCOPROTEINS

被引：2

作者：

GASNIER, F ^{[1
]}

ARDAIL, D ^{[1
]}

LERME, F ^{[1
]}

SIMONOT, C ^{[1
]}

VAGANAY, E ^{[1
]}

LOUISOT, P ^{[1
]}

GATEAUROESCH, O ^{[1
]}

机构：

[1] UNIV LYON, LYON SUD MED SCH, DEPT BIOCHEM, CNRS, INSERM, U189, F-69921 OULLINS, FRANCE

来源：

JOURNAL OF BIOCHEMISTRY | 1994年 / 116卷 / 03期

关键词：

MITOCHONDRIA; MITOCHONDRIAL OUTER MEMBRANE; SIALOGLYCOPROTEINS;

D O I：

10.1093/oxfordjournals.jbchem.a124574

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The distribution of sialic acid-containing glycoproteins was investigated in highly purified mitochondrial membranes using labeled Sambucus nigra agglutinin as a detection system. Two sialylated glycoproteins were shown to be true components of the mitochondrial outer membrane. Relative to monoamine oxidase activity, these glycoproteins were found to be preferentially located in the ''free'' outer membrane fraction. As sialic acid is thought to be involved in molecular recognition, a role for these glycoproteins in mediating the interactions between mitochondria and other sub-cellular organelles is considered.

引用

页码：643 / 648

页数：6

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