CONTROLLED-RELEASE FROM POLY(PHOSPHOESTER) MATRICES

被引：41

作者：

DAHIYAT, BI ^{[1
]}

RICHARDS, M ^{[1
]}

LEONG, KW ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,DEPT BIOMED ENGN,BALTIMORE,MD 21218

来源：

JOURNAL OF CONTROLLED RELEASE | 1995年 / 33卷 / 01期

基金：

美国国家科学基金会;

关键词：

POLY(PHOSPHOESTER) MATRIX; BIODEGRADABLE POLYMER;

D O I：

10.1016/0168-3659(94)00039-W

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A class of biodegradable polymers, poly(phosphoesters), was studied for its potential as a matrix for controlled drug delivery. The degradability of the phosphorus ester linkage and the versatility of phosphorus-containing polymers make poly(phosphoesters) attractive candidates for development as a degradable biomaterial. The release of various drugs in vitro from a series of bisphenol-A based poly(phosphoesters) was examined. Sustained release for up to several months was achieved for cortisone acetate and model drug p-nitroaniline. The mechanism of release was found to be a combination of diffusion, swelling and degradation. The structure of the sidechain influenced the release behavior in all instances.

引用

页码：13 / 21

页数：9

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