ELECTROSTATIC COUPLING BETWEEN MEMBRANE-PROTEINS

被引：20

作者：

BROWN, GC

机构：

[1] Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW England, Tennis Court Rd

来源：

FEBS LETTERS | 1990年 / 260卷 / 01期

关键词：

Bioenergetics; Electric field; intramembrane; Ion channel; Membrane protein; Signal transduction;

D O I：

10.1016/0014-5793(90)80051-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Charges on membrane proteins are argued to produce very large electric fields within the membrane which may be felt by neighbouring membrane proteins. The activity of many membrane proteins may be sensitive to the electric field in the membrane; thus one membrane protein may affect the activity of another via the local electric field without any contact between the two. More specific electrostatic interactions are possible with binding between the two proteins. The possible roles of such interactions in bioenergetics, neurophysiology and signal transduction are discussed. © 1990.

引用

收藏

页码：1 / 5

页数：5

相关论文

共 19 条

[1] DIRECT ACTIVATION OF CGMP-DEPENDENT CHANNELS OF RETINAL RODS BY THE CGMP PHOSPHODIESTERASE [J].

BENNETT, N ;

ILDEFONSE, M ;

CROUZY, S ;

CHAPRON, Y ;

CLERC, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (10) :3634-3638

[2] ARRANGEMENT OF PROTEINS IN THE MITOCHONDRIAL INNER MEMBRANE [J].

CAPALDI, RA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 694 (03) :291-306

[3] VOLTAGE DEPENDENCE OF THE NA-K PUMP [J].

DEWEER, P ;

GADSBY, DC ;

RAKOWSKI, RF .

ANNUAL REVIEW OF PHYSIOLOGY, 1988, 50 :225-241

[4] A FAMILY OF RECEPTORS COUPLED TO GUANINE-NUCLEOTIDE REGULATORY PROTEINS [J].

DOHLMAN, HG ;

CARON, MG ;

LEFKOWITZ, RJ .

BIOCHEMISTRY, 1987, 26 (10) :2657-2664

[5] FULLY DELOCALIZED CHEMIOSMOTIC OR LOCALIZED PROTON FLOW PATHWAYS IN ENERGY COUPLING - A SCRUTINY OF EXPERIMENTAL-EVIDENCE [J].

FERGUSON, SJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 811 (01) :47-95

[6] SODIUM-CHANNEL GATING - MODELS, MIMICS, AND MODIFIERS [J].

FRENCH, RJ ;

HORN, R .

ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING, 1983, 12 :319-356

[7]

GILMAN AG, 1987, ANNU REV BIOCHEM, V56, P615, DOI 10.1146/annurev.bi.56.070187.003151

[8]

HONIG BH, 1986, ANNU REV BIOPHYS BIO, V15, P163

[9] BATRACHOTOXIN MODIFIES THE GATING KINETICS OF SODIUM-CHANNELS IN INTERNALLY PERFUSED NEURO-BLASTOMA CELLS [J].

HUANG, LYM ;

MORAN, N ;

EHRENSTEIN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (06) :2082-2085

[10] LATERAL DIFFUSION OF PROTEINS IN MEMBRANES [J].

JACOBSON, K ;

ISHIHARA, A ;

INMAN, R .

ANNUAL REVIEW OF PHYSIOLOGY, 1987, 49 :163-175