INHIBITION OF PLASMODIUM-FALCIPARUM GROWTH BY A SYNTHETIC IRON CHELATOR

被引：15

作者：

IHEANACHO, EN

SAMUNI, A

AVRAMOVICIGRISARU, S

SAREL, S

SPIRA, DT

机构：

[1] HADASSAH MED SCH, KUVIN CTR STUDY INFECT & TROP DIS, POB 1172, IL-91010 JERUSALEM, ISRAEL

[2] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, DEPT MOLEC BIOL, IL-91010 JERUSALEM, ISRAEL

[3] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, DEPT PHARMACEUT CHEM, IL-91010 JERUSALEM, ISRAEL

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 02期

关键词：

D O I：

10.1016/0035-9203(90)90259-H

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The susceptibility of the chloroquine-resistant malaria parasite Plasmodium falciparum (FCR-3) to a pyridoxal-based iron chelator was tested. 10 μ m of the chelator 1 [n-ethoxycarbonylmethyl-pyridoxylidenium]-2-[2'-pyridyl] hydrazine bromide (code name L2-9) effectively inhibited growth in vitro of the parasites. Presaturation of the chelator with either ferric or ferrous iron partially blocked the inhibitory effect. Two hours' exposure of parasites to 20 L2-9 was sufficient to inhibit their growth irreversibly. Desferrioxamine blocked the inhibitory effect of L2-9. It is suggested that the chelator may be acting by generating free radicals in complexing intracellular iron. © 1990 Royal Society of Tropical Medicine and Hygiene.

引用

页码：213 / 216

页数：4

共 28 条

[1] LACTOFERRIN ENHANCES HYDROXYL RADICAL PRODUCTION BY HUMAN-NEUTROPHILS, NEUTROPHIL PARTICULATE FRACTIONS, AND AN ENZYMATIC GENERATING-SYSTEM [J].