EFFICACY OF CYCLOSPORINE-A FOR IDIOPATHIC PULMONARY FIBROSIS

被引：14

作者：

FUKAZAWA, M ^{[1
]}

KAWANO, M ^{[1
]}

HISANO, S ^{[1
]}

UEDA, K ^{[1
]}

MATSUBA, K ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DIS CHEST RES INST,FUKUOKA 812,JAPAN

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1990年 / 149卷 / 06期

关键词：

Corticosteroid; Cyclosporin A; Idiopathic pulmonary fibrosis;

D O I：

10.1007/BF02009669

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In an 11-year-old girl with severe dyspnoea and cyanosis, idiopathic pulmonary fibrosis (IPF) was diagnosed. The PaO2 of blood could be maintained between 50 mm Hg and 70 mm Hg with a high dose pulse corticosteroid therapy, although this dose could not be reduced. Azathioprine in addition to prednisolone provoked deterioration. Twelve weeks after admission, cyclosporin A (Cs A), a known immunosuppressant, was started together with prednisolone. The PaO2 reverted to normal within 1 month and prednisolone could be tapered off within 6 months. Two years after admission, the patient is free of symptoms on continuous Cs A therapy. This case seems to be the first case successfully treated with Cs A. © 1990 Springer-Verlag.

引用

页码：441 / 442

页数：2

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