THE FIRST EXAMPLE OF ASYMMETRIC DIHYDROXYLATION OF CYCLOPROPYLIDENE DERIVATIVES - AN ENANTIOENRICHED FORMAL TOTAL SYNTHESIS OF (-)-FILIFORMIN

被引：30

作者：

NEMOTO, H ^{[1
]}

MIYATA, J ^{[1
]}

HAKAMATA, H ^{[1
]}

FUKUMOTO, K ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 98077,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

D O I：

10.1016/0040-4039(94)02452-H

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of asymmetric dihydroxylation (AD) of the cyclopropylidene derivatives 4a-e followed by enantiospecific 1,2-rearrangement of the resulted diols 5a-e to give the optically active cyclobutanones 7a-e was reported. The synthesis of 7e constitutes an enantioenriched formal total synthesis of (-)-filiformin (8).

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页码：1055 / 1058

页数：4

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