Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth

被引:108
作者
Blain-Moraes, Stefanie [1 ]
Lee, UnCheol [1 ]
Ku, SeungWoo [2 ]
Noh, GyuJeong [2 ]
Mashour, George A. [1 ,3 ]
机构
[1] Univ Michigan, Sch Med, Ctr Consciousness Sci, Dept Anesthesiol, 1H247 UH SPC-5048,1500 East Med Ctr Dr, Ann Arbor, MI 48109 USA
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Anesthesiol, Seoul, South Korea
[3] Univ Michigan, Sch Med, Neurosci Grad Program, Ann Arbor, MI 48109 USA
关键词
ketamine; consciousness; general anesthesia; anesthetic-induced unconsciousness; anesthetic mechanisms;
D O I
10.3389/fnsys.2014.00114
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Recent studies of propofol-induced unconsciousness have identified characteristic properties of electroencephalographic alpha rhythms that may be mediated by drug activity at.-aminobutyric acid (GABA) receptors in the thalamus. However, the effect of ketamine (a primarily non-GABAergic anesthetic drug) on alpha oscillations has not been systematically evaluated. We analyzed the electroencephalogram of 28 surgical patients during consciousness and ketamine-induced unconsciousness with a focus on frontal power, frontal cross-frequency coupling, frontal-parietal functional connectivity (measured by coherence and phase lag index), and frontal-to-parietal directional connectivity (measured by directed phase lag index) in the alpha bandwidth. Unlike past studies of propofol, ketamine-induced unconsciousness was not associated with increases in the power of frontal alpha rhythms, characteristic cross-frequency coupling patterns of frontal alpha power and slow-oscillation phase, or decreases in coherence in the alpha bandwidth. Like past studies of propofol using undirected and directed phase lag index, ketamine reduced frontal-parietal (functional) and frontal-to-parietal (directional) connectivity in the alpha bandwidth. These results suggest that directional connectivity changes in the alpha bandwidth may be state-related markers of unconsciousness induced by both GABAergic and non-GABAergic anesthetics.
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页数:9
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