METABOLITES OF PHENCYCLIDINE

被引：68

作者：

WONG, LK ^{[1
]}

BIEMANN, K ^{[1
]}

机构：

[1] MIT, DEPT CHEM, CAMBRIDGE, MA 02139 USA

来源：

CLINICAL TOXICOLOGY | 1976年 / 9卷 / 04期

关键词：

D O I：

10.3109/15563657608988160

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Oxidative hydroxylation in rats is the major mode of metabolism of phencyclidine [a hallucinogen]. This process takes place in all 3 rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites. Metabolism of phencyclidine in humans appears, at least in part, to be similar to that in the rat. Hydroxylation is still the principal mode in the case of humans though of a lesser extent. Metabolites hydroxylated in the phenyl moiety as well as dihydroxy derivatives of phencyclidine have so far not been observed in humans. Most of the monohydroxy metabolites exist as conjugates in the human urine. No metabolites were detected in human blood samples.

引用

页码：583 / 591

页数：9

共 18 条

[1]

ANDRESEN BD, 1974, THESIS MIT

[2]

BILLER JE, 1974, ANAL LETT, V7, P515

[3]

BILLER JE, 1972, THESIS MIT

[4] ENZYMATIC METABOLISM OF DRUGS AND OTHER FOREIGN COMPOUNDS [J].