SEXUAL FUNCTION OF WOMEN TAKING ANTIHYPERTENSIVE AGENTS - A COMPARATIVE-STUDY

被引：21

作者：

HODGE, RH ^{[1
]}

HARWARD, MP ^{[1
]}

WEST, MS ^{[1
]}

KRONGAARDDEMONG, L ^{[1
]}

KOWALNEELEY, MB ^{[1
]}

机构：

[1] UNIV VIRGINIA,MED CTR,SCH MED,CHARLOTTESVILLE,VA 22901

来源：

JOURNAL OF GENERAL INTERNAL MEDICINE | 1991年 / 6卷 / 04期

关键词：

FEMALE SEXUAL FUNCTION; ANTIHYPERTENSIVE AGENTS; SIDE EFFECTS; QUESTIONNAIRE; CLONIDINE; PRAZOSIN;

D O I：

10.1007/BF02597423

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Objective: To develop a method to evaluate the effects of clonidine and prazosin on sexual function in hypertensive women. Design: Crossover, active-drug controlled pilot study. Setting: Community recruitment to a university-based teaching hospital. Patients: Ten premenopausal and eight postmenopausal women with mild hypertension and unimpaired sexual function. Intervention: Periodic, self-administered daily diaries assessed the sexual arousal and desire and orgasmic function of women receiving placebo, clonidine, and prazosin. Measurements and main results: Using analysis of variance for orgasmic characteristics and comparison of the percentages of yes responses to the sexual function questions, no significant difference in the levels of sexual function of women receiving placebo, clonidine, and prazosin was found. However, there was a suggestion that clonidine and prazosin affected some aspects of sexual function. Of the women who received clonidine first, fewer were receptive to partner approach during medication therapy (49%) than during placebo (61%). Fewer women wished for their partners to approach them (WISH) during therapy (41% and 53% for clonidine and prazosin, respectively) than during placebo (60%). In the group that received prazosin first, WISH was affected (32% for prazosin, 31% for clonidine, 45% for placebo). Orgasmic strength increased from 2.1 on placebo to 2.7 on clonidine (second medication), measured on a four-point Likert scale. Conclusions: This pilot study developed a method using self-administered daily diaries for evaluating the effects of antihypertensive agents on sexual function in hypertensive women. These potential effects need to be evaluated in larger studies.

引用

页码：290 / 294

页数：5

共 27 条

[1]

Freis E.D., Calabresi M.I., Castle C.H., Et al., Veterans Administration Cooperative Study Group on Antihypertensive Agents: effects of treatment on morbidity in hypertension: results in patients with diastolic blood pressures averaging 115 through 129 mm Hg, JAMA, 202, pp. 1028-34, (1969)

[2]

The 1988 report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure, Arch Intern Med, 148, pp. 1023-38, (1988)

[3]

Helgeland A., Treatment of mild hypertension: a five-year controlled drug trial, Am J Med, 69, pp. 725-32, (1980)

[4]

Five-year findings of the Hypertension Detection and Follow-up Program: I. Reduction in mortality of persons with high blood pressure, including mild hypertension, JAMA, 242, pp. 2562-71, (1979)

[5]

Five-year findings of the Hypertension Detection and Follow-up Program: II. Mortality by race, sex, and age, JAMA, 242, pp. 2572-7, (1979)

[6]

MRC trial of treatment of mild hypertension: principal results, Br Med J, 291, pp. 97-104, (1985)

[7]

Haynes R.B., Sackett D.L., Taylor D.W., Gibson E.S., Johnson A.L., Increased absenteeism from work after detection and labeling of hypertensive patients, N Engl J Med, 299, pp. 741-4, (1978)

[8]

Stevenson J.G., Utead G.S., Sexual dysfunction due to antihypertensive agents, Drug Intell Clin Pharm, 18, pp. 113-21, (1984)

[9]

Reichgott M.J., Problems of sexual function in patients with hypertension, Cardiovasc Med, 4, pp. 149-56, (1979)

[10]

Hogan M.J., Wallin J.D., Baer R.M., Antihypertensive therapy and male sexual dysfunction, Psychosomatics, 21, pp. 234-7, (1980)

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