DISPLACEMENT OF [H-3] GAMMA-HYDROXYBUTYRATE BINDING BY BENZAMIDE NEUROLEPTICS AND PROCHLORPERAZINE BUT NOT BY OTHER ANTIPSYCHOTICS

被引:23
作者
MAITRE, M
RATOMPONIRINA, C
GOBAILLE, S
HODE, Y
HECHLER, V
机构
[1] Centre de Neurochimie, UPR 416 du CNRS, 67084 Strasbourg cedex
关键词
GAMMA-HYDROXYBUTYRATE RECEPTOR; NEUROLEPTIC; BENZAMIDE; DOPAMINERGIC ACTIVITY;
D O I
10.1016/0014-2999(94)90248-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic regulatory properties and neuroleptic-like effects in neuropharmacological tests, the common neuroleptics were tested for [H-3]gamma-hydroxybutyrate binding activity on rat brain membranes. (-)-Sulpiride, sultopride, amisulpride and prochlorperazine possess affinity for the gamma-hydroxybutyrate site(s), consistent with their therapeutic dosage. This study has revealed that gamma-hydroxybutyrate receptors represent an additional target for antipsychotics.
引用
收藏
页码:211 / 214
页数:4
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