DISPLACEMENT OF [H-3] GAMMA-HYDROXYBUTYRATE BINDING BY BENZAMIDE NEUROLEPTICS AND PROCHLORPERAZINE BUT NOT BY OTHER ANTIPSYCHOTICS

被引：23

作者：

MAITRE, M

RATOMPONIRINA, C

GOBAILLE, S

HODE, Y

HECHLER, V

机构：

[1] Centre de Neurochimie, UPR 416 du CNRS, 67084 Strasbourg cedex

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 256卷 / 02期

关键词：

GAMMA-HYDROXYBUTYRATE RECEPTOR; NEUROLEPTIC; BENZAMIDE; DOPAMINERGIC ACTIVITY;

D O I：

10.1016/0014-2999(94)90248-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic regulatory properties and neuroleptic-like effects in neuropharmacological tests, the common neuroleptics were tested for [H-3]gamma-hydroxybutyrate binding activity on rat brain membranes. (-)-Sulpiride, sultopride, amisulpride and prochlorperazine possess affinity for the gamma-hydroxybutyrate site(s), consistent with their therapeutic dosage. This study has revealed that gamma-hydroxybutyrate receptors represent an additional target for antipsychotics.

引用

页码：211 / 214

页数：4

共 16 条

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