REACTIONS OF DIMESYLTHYMIDINE WITH SECONDARY-AMINES - EASY ACCESS TO 3',5'-DIDEOXY-3'-SUBSTITUTED-5'-ALKYLAMINOTHYMIDINES - NEW CLASSES OF POTENTIAL ANTIVIRAL AMINONUCLEOSIDES

被引：12

作者：

SAKTHIVEL, K ^{[1
]}

KUMAR, RK ^{[1
]}

PATHAK, T ^{[1
]}

机构：

[1] NATL CHEM LAB,ORGAN CHEM DIV SYNTH,BIOORGAN CHEM UNIT,POONA 411008,MAHARASHTRA,INDIA

来源：

TETRAHEDRON | 1993年 / 49卷 / 20期

关键词：

D O I：

10.1016/S0040-4020(01)85753-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3,5'-Di-O-mesylthymidine 4a (DMST) on reaction with secondary amines undergoes hitherto unknown ''one-pot-two-steps'' transformation to produce 2,3'-O-anhydro-5'-deoxy-5'-alkylaminothymidines 5a-h. Most of the amines used, irrespective of their basicities showed remarkable selectivity towards the 5'-substitution over the 2,3'-O-anhydro ring formation. Compounds 5a-h could be used as intermediates for the synthesis of a variety of 3,5'-dideoxy-3'-substituted-5'-alkylaminothymidines of the type 9, 10a-b, 11.

引用

页码：4365 / 4372

页数：8

共 31 条

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