NITRIC-OXIDE PRODUCTION AND MYCOBACTERIAL GROWTH-INHIBITION BY MURINE ALVEOLAR MACROPHAGES - THE SEQUENCE OF RIFN-GAMMA STIMULATION AND MYCOBACTERIUM-BOVIS BCG INFECTION DETERMINES MACROPHAGE ACTIVATION

被引：26

作者：

HANANO, R ^{[1
]}

KAUFMANN, SHE ^{[1
]}

机构：

[1] UNIV ULM,DEPT IMMUNOL,D-89070 ULM,GERMANY

来源：

IMMUNOLOGY LETTERS | 1995年 / 45卷 / 1-2期

关键词：

TUBERCULOSIS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE; INTERFERON-GAMMA; MYCOBACTERIUM BOVIS BCG; ALVEOLAR MACROPHAGE; DIAPHORASE;

D O I：

10.1016/0165-2478(94)00193-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prestimulation with recombinant-interferon-gamma (rIFN-gamma) followed by Mycobacterium bovis BCG infection induced high nitric oxide production and potent mycobacterial growth inhibition in murine alveolar macrophages. Reversal of the sequence of treatments caused opposite effects, suggesting that a sequential 2-step process comprising first rIFN-gamma stimulation and second mycobacterial infection is operative in the activation of alveolar macrophages.

引用

页码：23 / 27

页数：5