ON-COLUMN PREPARATION OF 1-AMINOCYCLOPENTANE-1-[C-11]CARBOXYLIC ACID

被引：4

作者：

IWATA, R ^{[1
]}

IDO, T ^{[1
]}

TADA, M ^{[1
]}

机构：

[1] TOHOKU UNIV,INST DEV AGING & CANC,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

APPLIED RADIATION AND ISOTOPES | 1995年 / 46卷 / 09期

关键词：

D O I：

10.1016/0969-8043(95)00146-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new, convenient on-column method using kieselguhr (Extrelut(R), Merck) has been developed for the synthesis of 1-aminocyclopentane-1-[C-11]carboxylic acid ([C-11]ACPC) from [C-11]HCN. The whole synthetic procedure, including the trapping and reaction of [C-11]HCN as well as the following extraction and acid hydrolysis, was remarkably simplified, and the preparation has been successfully accommodated to routine production of [C-11]ACPC. The established method provides radiochemically pure [C-11]ACPC in over 60% radiochemical yield within 40 min after the end of bombardment.

引用

页码：899 / 905

页数：7

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