Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment

被引：652

作者：

Volkova, Maria ^{[1
,2
]}

Russell, Raymond, III ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Sect Cardiovasc Med, New Haven, CT 06510 USA

[2] Smilow Canc Hosp, New Haven, CT 06510 USA

来源：

CURRENT CARDIOLOGY REVIEWS | 2011年 / 7卷 / 04期

关键词：

Left ventricular dysfunction; doxorubicin; oxidant stress;

D O I：

10.2174/157340311799960645

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.

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收藏

页码：214 / 220

页数：7

相关论文

共 84 条

[1]

Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer [J].

Abu-Khalaf, Maysa M. ;

Juneja, Vinni ;

Chung, Gina G. ;

DiGiovanna, Michael P. ;

Sipples, Rebecca ;

McGurk, Meghan ;

Zelterman, Daniel ;

Haffty, Bruce ;

Reiss, Michael ;

Wackers, Frans J. ;

Lee, Forrester A. ;

Burtness, Barbara A. .

BREAST CANCER RESEARCH AND TREATMENT, 2007, 104 (03) :341-349

[2]

SERIAL ASSESSMENT OF DOXORUBICIN CARDIOTOXICITY WITH QUANTITATIVE RADIONUCLIDE ANGIOCARDIOGRAPHY [J].

ALEXANDER, J ;

DAINIAK, N ;

BERGER, HJ ;

GOLDMAN, L ;

JOHNSTONE, D ;

REDUTO, L ;

DUFFY, T ;

SCHWARTZ, P ;

GOTTSCHALK, A ;

ZARET, BL .

NEW ENGLAND JOURNAL OF MEDICINE, 1979, 300 (06) :278-283

[3]

ADRIAMYCIN, 14-HYDROXYDAUNOMYCIN, A NEW ANTITUMOR ANTIBIOTIC FROM S-PEUCETIUS VAR CAESIUS [J].

ARCAMONE, F ;

CASSINEL.G ;

FANTINI, G ;

GREIN, A ;

OREZZI, P ;

POL, C ;

SPALLA, C .

BIOTECHNOLOGY AND BIOENGINEERING, 1969, 11 (06) :1101-&

[4]

Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction [J].

Berthiaume, JM ;

Oliveira, PJ ;

Fariss, MW ;

Wallace, KB .

CARDIOVASCULAR TOXICOLOGY, 2005, 5 (03) :257-267

[5]

BILLINGHAM ME, 1978, CANCER TREAT REP, V62, P865

[6]

Activity of d,l-α-tocopherol (vitamin E) against cardiotoxicity induced by doxorubicin and doxorubicin with cyclophosphamide in mice [J].

Bjelogrlic, SK ;

Radic, J ;

Jovic, V ;

Radulovic, S .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2005, 97 (05) :311-319

[7]

EARLY ANTHRACYCLINE CARDIOTOXICITY [J].

BRISTOW, MR ;

THOMPSON, PD ;

MARTIN, RP ;

MASON, JW ;

BILLINGHAM, ME ;

HARRISON, DC .

AMERICAN JOURNAL OF MEDICINE, 1978, 65 (05) :823-832

[8]

DOXORUBICIN CARDIOMYOPATHY - EVALUATION BY PHONOCARDIOGRAPHY, ENDOMYOCARDIAL BIOPSY, AND CARDIAC-CATHETERIZATION [J].

BRISTOW, MR ;

MASON, JW ;

BILLINGHAM, ME ;

DANIELS, JR .

ANNALS OF INTERNAL MEDICINE, 1978, 88 (02) :168-175

[9]

BUZDAR AU, 1985, CANCER, V55, P2761, DOI 10.1002/1097-0142(19850615)55:12<2761::AID-CNCR2820551206>3.0.CO

[10]

2-P

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