DIRECT N8-ALKYLATION OF 2,4-DIAMINO-7,8-DIHYDROPTERIDINES - PREPARATION OF 7,8-DIHYDRO-8-METHYLMETHOTREXATE

被引：11

作者：

CHAYKOVSKY, M ^{[1
]}

机构：

[1] HARVARD UNIV,MED SCH,SIDNEY FARBER CANC CTR,BOSTON,MA 02115

来源：

关键词：

D O I：

10.1021/jo00889a046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：145 / 146

页数：2

共 12 条

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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (06) : 1345 - +
[3] FUTTERMAN S, 1957, J BIOL CHEM, V228, P1031
[4] REACTION OF BIFUNCTIONAL ALKYLATING AGENTS WITH TETRAHYDROFOLATE
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OZOLS, JG
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[J]. BIOCHEMISTRY, 1967, 6 (07) : 2159 - &
[5] THYMINYL DERIVATIVES OF TETRAHYDROFOLATE
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[J]. BIOCHEMISTRY, 1967, 6 (07) : 2168 - &
[6] HOLLAND JF, 1973, CANCER MEDICINE, P739
[7] PTERIDINES .37. SYNTHESIS AND PROPERTIES OF 2,4-DIAMINOPTERIDINES AND THEIR 5,6,7,8-TETRAHYDRO DERIVATIVES
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PFLEIDER.W
[J]. CHEMISCHE BERICHTE-RECUEIL, 1970, 103 (03): : 722 - &
[8] MORALES DR, 1964, BIOCHIM BIOPHYS ACTA, V85, P360
[9] SLAVIK K, 1967, MOL PHARMACOL, V3, P370
[10] PTERIDINES .29. UNEQUIVOCAL ROUTE TO 2,4-DIAMINO-6-SUBSTITUTED PTERIDINES
TAYLOR, EC
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SWORD, IP
JACOBI, PA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (19) : 6413 - 6418