STUDIES IN FETAL WOUND-HEALING, .7. FETAL WOUND-HEALING MAY BE MODULATED BY HYALURONIC-ACID STIMULATING ACTIVITY IN AMNIOTIC-FLUID

被引:93
作者
LONGAKER, MT
ADZICK, NS
HALL, JL
STAIR, SE
CROMBLEHOLME, TM
DUNCAN, BW
BRADLEY, SM
HARRISON, MR
STERN, R
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PATHOL,HSW-501,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT SURG,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,FETAL TREATMENT PROGRAM,SAN FRANCISCO,CA 94143
关键词
amniotic fluid; Fetal wound healing; hyaluronic acid;
D O I
10.1016/0022-3468(90)90387-O
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Fetal wound healing occurs rapidly and without inflammation, fibrosis, or scar formation. It is a process fundamentally different from adult wound healing. The mechanisms that underlie such unique healing properties are unknown. However, hyaluronic acid, a glycosaminoglycan component of the extracellular matrix, is prominent throughout the course of fetal wound healing, and is thought to play a major role in the healing process. Amniotic fluid contains high levels of hyaluronic acid. Amniotic fluid also contains a number of potent growth factors that are critical for fetal development. In this report, a new factor in amniotic fluid that stimulates deposition of hyaluronic acid is described. This activity is measured in an in vitro assay system in which cultured fibrosarcoma cells are used as indicator cells. Amniotic fluid thus provides two separate mechanisms for the deposition of hyaluronic acid. One is by exogenous application directly onto fetal skin wounds; the second is by providing a factor to increase the production of hyaluronic acid endogenously, by stimulating cells around the wound site. The resulting hyaluronic acid-rich area may support the ability of the fetal wound to heal with its unique properties. © 1990.
引用
收藏
页码:430 / 433
页数:4
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