ACTIVITY OF CEFIXIME AGAINST HELICOBACTER-PYLORI AND AFFINITIES FOR THE PENICILLIN-BINDING PROTEINS

被引：17

作者：

IKEDA, F

YOKOTA, Y

MINE, Y

TATSUTA, M

机构：

[1] FUJISAWA PHARMACEUT CO LTD,PROD DEV LABS,DEPT CHEMOTHERAPY,1-6 2-CHOME,YODOGAWA KU,OSAKA 532,JAPAN

[2] CTR ADULT DIS,DEPT GASTROINTESTINAL ONCOL & GASTROENTEROL,OSAKA 537,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 12期

关键词：

D O I：

10.1128/AAC.34.12.2426

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cefixime induced the formation of rounded cells from the spiral bacillary form of Helicobacter pylori at the MIC or less. Three main penicillin-binding proteins, called A, B and C, were separated from H. pylori. Cefixime had the strongest affinity to penicillin-binding protein B. The binding of cefixime to this protein may induce the formation of rounded H. pylori cells.

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页码：2426 / 2428

页数：3

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