ARYL CYANOGUANIDINE POTASSIUM CHANNEL OPENERS

被引：24

作者：

ATWAL, KS

MORELAND, S

MCCULLOUGH, JR

OREILLY, BC

AHMED, SZ

NORMANDIN, DE

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, N. J. 08543-4000, P.O. Box 4000, Princeton

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80661-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To investigate whether potassium channel openers cromakalim (1) and pinacidil (2) share common pharmacophoric features, the combination compound 6a was prepared and evaluated for biological activity. The potent vasorelaxant/antihypertensive activity displayed by 6a and some of its analogs suggest cromakalim (1) and pinacidil (2) may share common pharmacophoric features.

引用

页码：83 / 86

页数：4

共 20 条

[1] A FACILE SYNTHESIS OF CYANOGUANIDINES FROM THIOUREAS
ATWAL, KS
AHMED, SZ
OREILLY, BC
[J]. TETRAHEDRON LETTERS, 1989, 30 (52) : 7313 - 7316
[2] 4-HETEROCYCLYLOXY-2H-1-BENZOPYRAN POTASSIUM CHANNEL ACTIVATORS
BERGMANN, R
EIERMANN, V
GERICKE, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (10) : 2759 - 2767
[3] SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF 4-(1,2-DIHYDRO-2-OXO-1-PYRIDYL)-2H-1-BENZOPYRANS AND RELATED-COMPOUNDS, NEW POTASSIUM CHANNEL ACTIVATORS
BERGMANN, R
GERICKE, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) : 492 - 504
[4] EVIDENCE THAT THE MECHANISM OF THE INHIBITORY-ACTION OF PINACIDIL IN RAT AND GUINEA-PIG SMOOTH-MUSCLE DIFFERS FROM THAT OF GLYCERYL TRINITRATE
BRAY, KM
NEWGREEN, DT
SMALL, RC
SOUTHERTON, JS
TAYLOR, SG
WEIR, SW
WESTON, AH
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (02) : 421 - 429
[5] RELAXANT ACTIVITY OF 4-AMIDO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-OLS AND 4-AMIDO-2H-1-BENZOPYRANS ON GUINEA-PIG ISOLATED TRACHEALIS
BUCKLE, DR
ARCH, JRS
FENWICK, AE
HOUGEFRYDRYCH, CSV
PINTO, IL
SMITH, DG
TAYLOR, SG
TEDDER, JM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (11) : 3028 - 3034
[6] SYNTHESIS AND SMOOTH-MUSCLE RELAXANT ACTIVITY OF A NEW SERIES OF POTASSIUM CHANNEL ACTIVATORS - 3-AMIDO-1,1-DIMETHYLINDAN-2-OLS
BUCKLE, DR
ARCH, JRS
EDGE, C
FOSTER, KA
HOUGEFRYDRYCH, CSV
PINTO, IL
SMITH, DG
TAYLOR, JF
TAYLOR, SG
TEDDER, JM
WEBSTER, RAB
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) : 919 - 926
[7] VARIATION IN THE AROMATIC RING OF CROMAKALIM - ANTIHYPERTENSIVE ACTIVITY OF PYRANOPYRIDINES AND 6-ALKYL-2H-1-BENZOPYRANS
BURRELL, G
CASSIDY, F
EVANS, JM
LIGHTOWLER, D
STEMP, G
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (11) : 3023 - 3027
[8] THE PHARMACOLOGY OF POTASSIUM CHANNELS AND THEIR THERAPEUTIC POTENTIAL
COOK, NS
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (01) : 21 - 28
[9] STRUCTURE-ACTIVITY-RELATIONSHIPS OF K+ CHANNEL OPENERS
EDWARDS, G
WESTON, AH
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (10) : 417 - 422
[10] LAFFIN RJ, 1978, PHARM EXP THER, V204, P287

← 1 2 →