AN ALPHA-HELICAL HYDROPHOBIC HAIRPIN AS A SPECIFIC DETERMINANT IN PROTEIN-PROTEIN INTERACTION OCCURRING IN ESCHERICHIA-COLI COLICIN-A AND COLICIN-B IMMUNITY SYSTEMS

被引:37
作者
GELI, V
LAZDUNSKI, C
机构
关键词
D O I
10.1128/JB.174.20.6432-6437.1992
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A collection of chimeric pore-forming domains between colicins A and B was constructed to investigate the specific determinants responsible for recognition by the corresponding immunity proteins. The fusion sites in the hybrid proteins were positioned according to the three-dimensional structure of the soluble form of the colicin A pore-forming domain. The hydrophobic hairpin of colicin pore-forming domains, buried in the core of the soluble structure, was the main determinant recognized by the integral immunity proteins. The immunity protein function may require helix-helix recognition within the lipid bilayer.
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页码:6432 / 6437
页数:6
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