THE ASSESSMENT OF THE SCALE-UP PERFORMANCE OF THE EXTRUSION/SPHERONISATION PROCESS

被引：19

作者：

NEWTON, JM ^{[1
]}

CHAPMAN, SR ^{[1
]}

ROWE, RC ^{[1
]}

机构：

[1] ZENECA PHARMACEUT,MACCLESFIELD SK10 2NA,CHESHIRE,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 120卷 / 01期

关键词：

EXTRUSION SPHERONISATION; ROUNDNESS; SCALE-UP;

D O I：

10.1016/0378-5173(94)00425-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability to predict the spheronisation performance of a standard extrudate over a 125-fold range has been assessed in terms of spheroid quality produced. It has been found possible to predict the performance of a 25 kg batch on a 65.6 cm diameter production spheroniser from experiments (with a 22.9 cm diameter laboratory spheroniser). To achieve such prediction it is necessary to use a good quality extrudate and operate the spheroniser at rotational speeds which give the same linear peripheral velocity of the plate.

引用

页码：95 / 99

页数：5