SYNTHESIS, CONFORMATIONAL CONSIDERATIONS, AND ESTROGEN-RECEPTOR BINDING OF DIASTEREOISOMERS AND ENANTIOMERS OF 1-[4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-1,2-DIPHENYLBUTANE (DIHYDROTAMOXIFEN)

被引：21

作者：

MCCAGUE, R ^{[1
]}

LECLERCQ, G ^{[1
]}

机构：

[1] INST JULES BORDET,SERV MED,CANCEROL MAMMAIRE LAB,B-1000 BRUSSELS,BELGIUM

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 10期

关键词：

D O I：

10.1021/jm00393a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1761 / 1767

页数：7

共 33 条

[1]

ADAM HK, 1979, BIOCHEM PHARMACOL, V27, P145

[2] QUANTITATIVE REMOVAL OF A PENTADECAPEPTIDE ACTH FRAGMENT ANALOG FROM A MERRIFIELD RESIN USING AMMONIUM FORMATE CATALYTIC TRANSFER HYDROGENATION - SYNTHESIS OF [ASP25,ALA26,GLY27,GLN30]-ACTH-(25-39)-OH [J].

ANWER, MK ;

SPATOLA, AF ;

BOSSINGER, CD ;

FLANIGAN, E ;

LIU, RC ;

OLSEN, DB ;

STEVENSON, D .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (20) :3503-3507

[3] ANTIESTROGENIC AND ANTIFERTILITY COMPOUNDS .4. 1,1,2-TRIARYLALKAN-1-OLS AND 1,1,2-TRIARYLALK-1-ENES CONTAINING BASIC ETHER GROUPS [J].

COLLINS, DJ ;

HOBBS, JJ ;

EMMENS, CW .

JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (10) :952-&

[4] DETERMINATION OF TAMOXIFEN AND AN HYDROXYLATED METABOLITE IN PLASMA FROM PATIENTS WITH ADVANCED BREAST-CANCER USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY [J].

DANIEL, CP ;

GASKELL, SJ ;

BISHOP, H ;

NICHOLSON, RI .

JOURNAL OF ENDOCRINOLOGY, 1979, 83 (03) :401-408

[5] HYDROXY DERIVATIVES OF TAMOXIFEN [J].

FOSTER, AB ;

JARMAN, M ;

LEUNG, OT ;

MCCAGUE, R ;

LECLERCQ, G ;

DEVLEESCHOUWER, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (10) :1491-1497

[6] THE PHARMACOLOGY AND CLINICAL USES OF TAMOXIFEN [J].

FURR, BJA ;

JORDAN, VC .

PHARMACOLOGY & THERAPEUTICS, 1984, 25 (02) :127-205

[7] CONTRASTING ENDOCRINE ACTIVITIES OF CIS AND TRANS ISOMERS IN A SERIES OF SUBSTITUTED TRIPHENYLETHYLENES [J].

HARPER, MJK ;

WALPOLE, AL .

NATURE, 1966, 212 (5057) :87-&

[8]

JARMAN M, 1986, ANTI-CANCER DRUG DES, V1, P259

[9] MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTI-ESTROGENIC ACTIVITY [J].

JORDAN, VC ;

COLLINS, MM ;

ROWSBY, L ;

PRESTWICH, G .

JOURNAL OF ENDOCRINOLOGY, 1977, 75 (02) :305-316

[10]

JORDAN VC, 1984, PHARMACOL REV, V36, P245

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