WATER-SOLUBLE PRADIMICIN DERIVATIVES, SYNTHESIS AND ANTIFUNGAL EVALUATION OF N,N-DIMETHYL PRADIMICINS

被引：36

作者：

OKI, T

KAKUSHIMA, M

NISHIO, M

KAMEI, H

HIRANO, M

SAWADA, Y

KONISHI, M

机构：

[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 10期

关键词：

D O I：

10.7164/antibiotics.43.1230

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three N,N-dimethyl pradimicins were synthesized by reductive alkylation of pradimicins A, E and FA-2 and evaluated for antifungal activity, water solubility and acute toxicity in mice. They showed in vitro antifungal activity superior to pradimicin A. N,N-Dimethylpradimicins E and FA-2 showed great improvement in water solubility and animal tolerance. N,N-Dimethylpradimicin FA-2 was effective in 3 experimental in vivo fungal infection models. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：1230 / 1235

页数：6

共 10 条

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