STRUCTURE OF 6-O-METHYLERYTHROMYCIN-A (CLARITHROMYCIN)

被引：36

作者：

IWASAKI, H ^{[1
]}

SUGAWARA, Y ^{[1
]}

ADACHI, T ^{[1
]}

MORIMOTO, S ^{[1
]}

WATANABE, Y ^{[1
]}

机构：

[1] TAISHO PHARMACEUT CO LTD,RES CTR,OMIYA,SAITAMA 330,JAPAN

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1993年 / 49卷

关键词：

D O I：

10.1107/S0108270193000186

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The absolute configuration of the asymmetric centers in clarithromycin is the same as that in erythromycin A [Harris, McGeachin & Mills (1965). Tetrahedron Lett. pp. 679-685; Oliver & Strickland (1986). Acta Cryst. C42, 952-956]. The molecular structure is similar to that of erythromycin A. The carbonyl and the hydroxyl groups of the 14-membered aglycone are on the same side of the aglycone ring, and the 6-O-methyl group is in this hydrophilic region.

引用

页码：1227 / 1230

页数：4

共 12 条

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NAGATE, T
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[10] STRUCTURE OF A DIHYDRATED, DI-TERT-BUTYL ALCOHOL SOLVATED ZINC ACETATE COMPLEX WITH ERYTHROMYCIN-A AT 188-K
OLIVER, JD
STRICKLAND, LC
[J]. ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1986, 42 : 952 - 956

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