ANTITUMOR ACTION OF RETINOIDS - INHIBITION OF TUMOR-CELL LINE-INDUCED ANGIOGENESIS AND PREVENTION OF TUMORS IN MICE

被引：10

作者：

SZMURLO, A ^{[1
]}

MARCZAK, M ^{[1
]}

JABLONSKA, S ^{[1
]}

BOLLAG, W ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD, PHARMACEUT RES, CH-4002 BASEL, SWITZERLAND

来源：

DERMATOLOGY | 1992年 / 184卷 / 02期

关键词：

ANTITUMOR ACTIVITY; RETINOIDS; TUMOR-INDUCED ANGIOGENESIS;

D O I：

10.1159/000247516

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Acitretin was shown to inhibit angiogenic response to the tumorigenic SKV cell line bearing HPV16 genome and to sarcoma L-1 cell line, both in vitro and in vivo systems. The lowered angiogenic response to tumor cells was independent of duration and timing of the application of acitretin to animals. Acitretin, but not etretinate, was also found to be effective in the prevention of sarcoma tumors in mice.

引用

页码：116 / 119

页数：4

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