INHIBITORY EFFECT OF CHLOROPHYLLIN ON PHIP-INDUCED MAMMARY CARCINOGENESIS IN FEMALE F344 RATS

被引:73
作者
HASEGAWA, R [1 ]
HIROSE, M [1 ]
KATO, T [1 ]
HAGIWARA, A [1 ]
BOONYAPHIPHAT, P [1 ]
NAGAO, M [1 ]
ITO, N [1 ]
SHIRAI, T [1 ]
机构
[1] NATL CANC CTR,RES INST,DIV CARCINOGENESIS,CHUO KU,TOKYO 104,JAPAN
关键词
D O I
10.1093/carcin/16.9.2243
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Chlorophyll and chlorophyllin, a water-soluble salt of chlorophyll, have been reported to inhibit carcinogen-DNA binding and exert antimutagenic activity for some carcinogenic heterocyclic amines and aflatoxins, In the present experiment, the possible inhibitory effects of chlorophyllin on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenicity were investigated, Female F344 rats were administered both PhIP, 0.02% in the diet, and chlorophyllin, 1% in the diet (group 1), or either PhIP (group 2) or chlorophyllin (group 3) alone for 54 weeks, The incidence of mammary adenocarcinomas induced by PhIP was reduced by chlorophyllin co-administration from 40% (8/20 rats) to 15% (3/20), While the difference was not statistically significant, the multiplicity of adenocarcinomas was significantly (P < 0.05) reduced by chlorophyllin co-administration from 0.50 per animal to 0.15, On the other hand, incidence of colon adenomas was slightly, but not significantly, increased from 10% to 20%, Neither mammary nor colon adenocarcinomas were observed in group 3, Thus, chlorophyllin reduced PhIP mammary carcinogenesis, suggesting that chlorophyllin is an effective chemopreventor when ingested simultaneously with the carcinogen.
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页码:2243 / 2246
页数:4
相关论文
共 37 条
[1]   MUTAGENICITY OF FOOD PELLETS FROM HUMAN DIETS IN THE NETHERLANDS [J].
ALINK, GM ;
KNIZE, MG ;
SHEN, NH ;
HESSE, SP ;
FELTON, JS .
MUTATION RESEARCH, 1988, 206 (03) :387-393
[2]   INHIBITION OF THE MUTAGENICITY OF AMINO-ACID PYROLYSIS PRODUCTS BY HEMIN AND OTHER BIOLOGICAL PYRROLE PIGMENTS [J].
ARIMOTO, S ;
OHARA, Y ;
NAMBA, T ;
NEGISHI, T ;
HAYATSU, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 92 (02) :662-668
[3]  
BREINHOLT V, 1995, CANCER RES, V55, P57
[4]  
CHIPCHASE MIH, 1961, BIOCH HDB, P1032
[5]   INHIBITION OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE (IQ) DNA-BINDING BY CHLOROPHYLLIN - STUDIES OF ENZYME-INHIBITION AND MOLECULAR-COMPLEX FORMATION [J].
DASHWOOD, R ;
GUO, D .
CARCINOGENESIS, 1992, 13 (07) :1121-1126
[7]   CHEMOPREVENTIVE PROPERTIES OF CHLOROPHYLLIN - INHIBITION OF AFLATOXIN-B1 (AFB1)-DNA BINDING INVIVO AND ANTIMUTAGENIC ACTIVITY AGAINST AFB1 AND 2 HETEROCYCLIC AMINES IN THE SALMONELLA MUTAGENICITY ASSAY [J].
DASHWOOD, RH ;
BREINHOLT, V ;
BAILEY, GS .
CARCINOGENESIS, 1991, 12 (05) :939-942
[8]   ADDUCTION OF THE HETEROCYCLIC AMINE FOOD MUTAGENS IQ AND PHIP TO MITOCHONDRIAL AND NUCLEAR-DNA IN THE LIVER OF FISCHER-344 RATS [J].
DAVIS, CD ;
SCHUT, HAJ ;
SNYDERWINE, EG .
CARCINOGENESIS, 1994, 15 (04) :641-645
[9]   MEAT, COOKING METHODS AND COLORECTAL-CANCER - A CASE-REFERENT STUDY IN STOCKHOLM [J].
DEVERDIER, MG ;
HAGMAN, U ;
PETERS, RK ;
STEINECK, G ;
OVERVIK, E .
INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (04) :520-525