NEURONAL NICOTINIC RECEPTORS - FUNCTION, MODULATION AND STRUCTURE

被引：33

作者：

ALBUQUERQUE, EX ^{[1
]}

PEREIRA, EFR ^{[1
]}

CASTRO, NG ^{[1
]}

ALKONDON, M ^{[1
]}

机构：

[1] UFRJ,INST BIOFIS CARLOS CHAGAS FILHO,MOLEC PHARMACOL LAB 2,BR-21944 RIO JANEIRO,BRAZIL

来源：

SEMINARS IN THE NEUROSCIENCES | 1995年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

WHOLE-CELL CURRENTS; SINGLE-CHANNEL CURRENTS; NICOTINE; EPIBATIDINE; PHYSOSTIGMINE; PHOSPHOCREATINE; MAGNESIUM;

D O I：

10.1006/smns.1995.0011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present paper; we discuss the diversity of nicotinic receptors (nAChRs) expressed in hippocampal neurons and their functional properties. Three distinct types of whole-cell currents can be identified in hippocampal neurons by brief application of nicotinic agonists. These currents, which are referred to as types IA, II and III, were distinguished pharmacologically on the basis of their differential sensitivities to various nicotinic agonists and antagonists, and functionally on the basis of their rectification properties and rundown. Most of the hippocampal neurons show type IA current in response to nicotinic agonists, and the single channels that account for these currents in addition to having a very short open time and a high conductance, have a high Ca2+ permeability and inactivate very fast. Based on the comparison of the properties of the nicotinic currents elicited in hippocampal neurons with those elicited by activation of nAChRs transiently expressed in oocytes, we have concluded that type IA currents may be subserved by alpha 7-bearing nAChRs, type II currents by alpha 4 beta 2 nAChRs, and type III currents by alpha 3 beta 4 nAChRs. Indeed in-situ hybridization shows that mRNAs coding for alpha 7, alpha 4 and beta 2 nAChR subunits are present in hippocampal neurons. These findings altogether have given new insights for the studies of neurophysiological processes and neuropathological conditions in which neuronal nAChRs may be implicated.

引用

页码：91 / 101

页数：11

共 37 条

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