SOMATO-SYMPATHETIC REFLEX TRANSMISSION IN THE VENTROLATERAL MEDULLA-OBLONGATA - SPATIAL-ORGANIZATION AND RECEPTOR TYPES

被引:20
作者
ZANZINGER, J
CZACHURSKI, J
OFFNER, B
SELLER, H
机构
[1] I. Physiologisches Institut, Universität Heidelberg, D-69120 Heidelberg
关键词
SOMATO-SYMPATHETIC REFLEX; ROSTRAL VENTROLATERAL MEDULLA; SPINAL REFLEX; SUPRASPINAL REFLEX; SYMPATHETIC NERVE; BRAIN STEM; CAT;
D O I
10.1016/0006-8993(94)91479-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Tonic sympathetic activity in vivo is continuously modulated by inhibitory and excitatory reflex mechanisms. We studied the properties of somato-sympathetic excitatory reflex transmission in the rostral ventrolateral medulla (RVLM) of baroreceptor-denervated and vagotomized chloralose-anesthetized cats. Electrical stimulation of the left intercostal nerve of the 4th thoracic segment (IC-T4) elicited an early spinal and a late supraspinal reflex in the ipsilateral white ramus T3 from which recordings were made. Bilateral cooling of the ventral surface of the RVLM reversibly reduced the supraspinal reflex amplitude to 18.0+/-3.1% of control (100%). The spinally evoked reflex was enhanced to maximally 154.7+/-5.3%. Cooling of only the ipsilateral side of the RVLM was nearly equieffective in both, suppressing the supraspinal and enhancing the spinal reflex component. In contrast, cooling of the contralateral side had no significant effects on supraspinal reflex transmission but caused slight increases of the spinal reflex amplitudes. Similar effects were obtained by microinjection (RVLM) of the glutamate antagonist kynurenic acid (5 x 10(-3) M, n = 7) and the specific non-NMDA receptor antagonist CNQX (4 x 10(-3) M, n = 4) which, however, blocked the supraspinal reflex less effectively. These results demonstrate that the RVLM represents an essential relay in the transmission of both somatosympathetic reflex components. The experiments further suggest an almost completely ipsilateral neuronal pathway for the supraspinal reflex component which projects from the RVLM to the intermediolateral cell column (IML). The descending inhibition of the spinal reflex, however, receives neuronal inputs from the contralateral side.
引用
收藏
页码:353 / 358
页数:6
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